Table 3.

Univariate and Multivariate Analysis: All Patients

Variables	No. of Patients	Median Survival (moths)	p Valuea (Univariate)	HR	95% CIa	p valueb (Multivariate)	HR	95% CI
Treatment
Surgery only	401	13	0.077	1		–	–	–
Multimodal	203	19		0.84	0.69–1.02
Tumor site
Upper esophagus	25	16	0.371	1		–	–	–
Middle esophagus	87	14	0.946	0.98	0.58–1.66
Lower esophagus	268	14	0.658	1.16	0.69–1.81
EG junction	224	14	0.624	1.13	0.69–1.84
Depth of invasion
T0	57	55	<0.001	1		0.652	1
T1	68	26	0.537	1.16	0.73–1.83	0.472	0.71	0.21–2.3
T2	81	26	0.419	1.20	0.77–1.85	0.573	1.11	0.31–3.94
T3	373	11	<0.001	2.28	1.60–3.26	0.871	1.40	0.79–2.41
T4	19	7	<0.001	4.34	2.46–7.68	0.649	2.59	1.42–4.08
No. of nodes
0	289	26	<0.001	1		<0.001	1	0.63–1.87
1	84	16	0.038	1.36	1.02–1.82	0.774	1.08	0.83–2.43
2–3	84	11	<0.001	1.91	1.45–2.52	0.202	1.42	1.07–3.18
>3	147	8	<0.001	2.61	2.08–3.29	0.027	1.84
Histology
Squamous	361	14	0.916	1
Adenocarcinoma	224	13	0.596	1.05	0.87–1.28	–	–	–
Other	19	26	0.483	0.80	0.44–1.48
Stage
0	53	55	<0.001	1		0.118	1
I	63	55	0.747	0.92	0.56–1.51	0.576	0.68	0.18–2.59
II	230	20	0.037	1.49	1.02–2.17	0.508	1.55	0.42–4.69
III	225	10	<0.001	2.71	1.86–3.95	0.527	1.68	0.34–5.58
IV	31	6	<0.001	6.16	3.72–10.2	0.182	3.14	1.14–7.76
Residual tumor
R0	492	17	<0.001	1		0.052	1
R1	110	8		1.70	1.37–2.12		1.25	0.99–1.58

^aχ²

^bCox regression

HR = hazard ratio, CI = 95% confidence intervals, EG = esophagogastric