Table 2.
Coverage (percentage of True Positives identified before the first False Positive) and the average percentage of errors per sequence at the MEP of HMM-d and HMM-ModE for classification of Level-2 sub-families of Class A and Class C GPCR proteins
| Coverage | Average errors per sequence at MEP | |||||||
| HMM-ModE | HMM-d | HMM-ModE | HMM-d | |||||
| Set0 | Set1 | Set0 | Set1 | Set0 | Set1 | Set0 | Set1 | |
| Acetylcholine_muscarinic | 1 | 1 | 1 | 0.92 | 0 | 0 | 0 | 0.08 |
| Adenosine | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| Adrenoceptors | 0.48 | 0.97 | 0.45 | 0.97 | 0.06 | 0.03 | 0.06 | 0.03 |
| Adrenomedullin_G10D | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| Angiotensin | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| APJlike | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| Bombesin | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| Bradykinin | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| C5aanaphylatoxin | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| CCK | 1 | 0.89 | 1 | 0.89 | 0 | 0.11 | 0 | 0.11 |
| Chemokinereceptor_like | 0.5 | 0.8 | 0.5 | 0.8 | 0.5 | 0.2 | 0.5 | 0.2 |
| Chemokine | 1 | 0.55 | 0.98 | 0.55 | 0 | 0.09 | 0.02 | 0.11 |
| Dopamine | 0.87 | 0.91 | 0.87 | 0.91 | 0.13 | 0.09 | 0.13 | 0.09 |
| Endothelin | 1 | 1 | 1 | 0.88 | 0.29 | 0 | 0.29 | 0.13 |
| Fmet_leu_phe | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| Folliclestimulatinghormone | 0.86 | 1 | 0.86 | 1 | 0.14 | 0 | 0.14 | 0 |
| GABA_Bsubtype1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| GABA_Bsubtype2 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| Galaninlike | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| GP40like | 1 | 1 | 1 | 0.5 | 0 | 0 | 0 | 0.5 |
| GPR | 0.76 | 0.73 | 0.76 | 0.73 | 0.24 | 0.27 | 0.24 | 0.27 |
| Growthhormonesecretagoguelike | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| Growthhormonesecretagogue | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| Histamine | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| Interleukin_8 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| LeukotrieneB4receptorBLT1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| Lutropin_choriogonadotropichormone | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| Melanocortin | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| MetabotropicglutamategroupIII | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| MetabotropicglutamategroupII | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| MetabotropicglutamategroupI | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| Metabotropicglutamateother | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| NeuropeptideY | 0.88 | 1 | 0.88 | 1 | 0.13 | 0 | 0.13 | 0 |
| Neurotensin | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| Octopamine | 0.29 | 1 | 0.29 | 1 | 0.71 | 0 | 0.71 | 0 |
| OlfactoryIIfam10 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| OlfactoryIIfam1 | 0.86 | 0.80 | 0.86 | 0.80 | 0.14 | 0.10 | 0.14 | 0.10 |
| OlfactoryIIfam2 | 1 | 1 | 0.88 | 1 | 0 | 0 | 0.13 | 0 |
| OlfactoryIIfam3 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| OlfactoryIIfam5 | 1 | 0.71 | 1 | 0.71 | 0 | 0.29 | 0 | 0.29 |
| OlfactoryIIfam6 | 0.83 | 1 | 1 | 1 | 0.17 | 0 | 0 | 0 |
| OlfactoryIIfam7 | 1 | 1 | 1 | 0.86 | 0 | 0 | 0 | 0.14 |
| OlfactoryIIfam8 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| Opioid | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| Orexin_neuropeptideFF | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| PlateletADP_KI01receptors | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| Prostacyclin | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| Prostaglandin | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| Proteinase_activatedlike | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| Purinoceptors | 1 | 1 | 0.91 | 1 | 0 | 0 | 0.09 | 0 |
| RDC1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| RhodopsinArthropod | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| RhodopsinMollusc | 0.6 | 1 | 0.6 | 1 | 0.4 | 0 | 0.4 | 0 |
| RhodopsinOther | 0.86 | 0.67 | 0.71 | 0.50 | 0.14 | 0.33 | 0.29 | 0.50 |
| RhodopsinVertebrate | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| Serotonin | 0.94 | 0.94 | 0.94 | 0.94 | 0.06 | 0.06 | 0.06 | 0.06 |
| Somatostatin | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| Tachykinin | 0.92 | 1 | 0.92 | 1 | 0.08 | 0 | 0.08 | 0 |
| Thromboxane | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| Thyrotropin_releasinghormone | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| Thyrotropin | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| UrotensinII | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| Vasopressin_like | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| Masproto_oncogene | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| GPR37_endothelinB_like | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 |
| Average | 0.95 | 0.97 | 0.94 | 0.95 | 0.06 | 0.05 | 0.07 | 0.07 |
| Average(set0,set1) | 0.96 | 0.95 | 0.06 | 0.07 | ||||