Table 1.
Set | Ascertainment | Total | Definition of target | Positives |
'Known' | Unknown, complex | 12 | Low-throughput experimental characterization | 12 |
'Unbiased' | randomly chosen proteins | 198 | Score > 2 in high-throughput assay | 18 |
'2+' | All S. cerevisiae proteins containing two or more matches to the 'strong' CDK consensus | 385 | Score > 2 in high-throughput assay | 143 |
'1cc' | All S. cerevisiae proteins containing one match to the 'strong' CDK consensus and exhibiting cell cycle regulated transcription | 137 | Score > 2 in high-throughput assay | 32 |
Four cyclin-dependent kinase (CDK) target sets from Saccharomyces cerevisiae [11]. Note that only the high-throughput data contain 'negatives'. The 'strong' CDK consensus is S/T-P-X-R/K, where X represents any amino acid.