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. 2007 Feb 27;8(2):R27. doi: 10.1186/gb-2007-8-2-r27

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Copyright © 2007 Perkins et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Transcription yields a continuous supply of some types of pri-miRNA transcripts, capped and polyadenylated. hnRNPs are hypothesized to shape the pri-miRNA into linear and hairpin sections. A signaling system somehow recruits and activates unknown factors that select particular pre-miRNA hairpins on a particular pri-miRNA for excision and processing in the miRNA pathway. We hypothesize that this system might include a binding motif. RNASEN and DGCR8 are products of genes 29102 and 54487.