. Author manuscript; available in PMC: 2007 Apr 17.

Published in final edited form as: Otolaryngol Head Neck Surg. 2007 Apr;136(4):589–596. doi: 10.1016/j.otohns.2006.11.039

Table 1.

Experimental Design (summarizing the number of rats used in each cohort)

Routes of inoculation and the size of the S. pneumoniae inoculum in colony- forming units (CFU)	Cochleostomy only (control)	Cochleostomy and cochlear implantation	Cochleostomy and acute cochlear implantation
Intraperitoneal: 4 x 10⁶ CFU	6	6	6
Middle Ear: 3 x 10⁴ CFU	6	6	6
Inner Ear: 1 x 10³ CFU	6	6	6

The number of animals used and the size of the inoculum for each route were based on previous work.

The bacterial counts for each inoculation route has shown not to induce meningitis in 3 groups of 6 healthy rats with cochleotomy over 5 days of monitored infection period.⁶