Table 1.
Legend: Correlations between total histological score and tested cytokines in the Hartley guinea pig. Results are organized by likely association and statistical significance.
| Variation Between Hartley and Strain 13 Serum Concentrations | Association with Total Histology [r^2, p] | Likely Cause of Variation in Serum Concentrations |
|---|---|---|
| Significant | ||
| IL-6 | 0.20, 0.016* | OA |
| G-CSF | 0.18, 0.024* | OA |
| IL-2 | 0.16, 0.032 | OA |
| IL-12p70 | 0.17, 0.036 | OA |
| IL-5 | 0.15, 0.042 | OA |
| GM-CSF | 0.17, 0.044 | OA |
| IL-17 | 0.16, 0.047 | OA |
| IL-3 | 0.13, 0.068 | Strain Related Variation |
| IL-8 | 0.09, 0.137 | Strain Related Variation |
| MIP-1α | 0.08, 0.150 | Strain Related Variation |
| IL-12p40 | 0.09, 0.150 | Strain Related Variation |
| RANTES | 0.05, 0.270 | Strain Related Variation |
| Not Significant | ||
| IL-1β | 0.23, 0.011 | Age/OA |
| TNF-α | 0.18, 0.023 | Age/OA |
| IL-10† | 0.20, 0.031 | Weight, Age/OA |
| IFN-γ | 0.09, 0.150 | Age |
*
Significant according to Holm step-down p-values.
†
Displayed a significant correlation with Weight [0.17, 0.047]