Table 1.

Biodistribution of 7’(Z)-[¹²⁵I]iodorotenol (8) in Sprague-Dawley male rats

Tissue	1 h (n=3)	2 h (n=4)	24 h (n=4)
blood	0.259 ± 0.027	0.297 ± 0.031	0.080 ± 0.013
heart	1.698 ± 0.074	1.586 ± 0.240	0.241 ± 0.042
lung	0.548 ± 0.035	0.521 ± 0.050	0.078 ± 0.017
liver	1.497 ± 0.104	1.376 ± 0.151	0.138 ± 0.018
kidney	0.934 ± 0.009	0.822 ± 0.062	0.109 ± 0.009
spleen	0.364 ± 0.024	0.335 ± 0.026	0.047 ± 0.005
muscle	0.518 ± 0.093	0.491 ± 0.046	0.086 ± 0.012
fat	1.066 ± 0.269	1.469 ± 0.385	0.213 ± 0.038
brain	0.427 ± 0.030	0.297 ± 0.023	0.015 ± 0.002
thyroida	0.139 ± 0.047	0.241 ± 0.072	5.037 ± 2.376
heart:blood	6.600 ± 0.645	5.316 ± 0.363	3.016 ± 0.303
heart:lung	3.107 ± 0.203	3.081 ± 0.629	3.199 ± 0.892
heart:liver	1.136 ± 0.048	1.151 ± 0.109	1.755 ± 0.207

Male Sprague-Dawley rats (∼200 grams) were injected iv with 15-20 μCi of Z-[¹²⁵I]iodorotenol in 10% ethanol saline.

Tissue distribution values are given as percent injected dose / gram and presented as mean ± standard deviation.

^aThyroid values are given as percent injected dose/ organ.