Table 2.

Biodistribution of 7’ (Z)-[¹²⁵I]iodorotenone (9) in Sprague-Dawley male rats

Tissue	1 h (n=7)	2 h (n=6)	24 h (n=4)
blood	0.130 ± 0.020	0.135 ± 0.019	0.063 ± 0.010
heart	3.707 ± 0.203	2.959 ± 0.244	0.607 ± 0.109
lung	0.352 ± 0.055	0.326 ± 0.050	0.102 ± 0.017
liver	1.557 ± 0.201	1.169 ± 0.188	0.267 ± 0.052
kidney	1.257 ± 0.118	0.933 ± 0.092	0.212 ± 0.037
spleen	0.275 ± 0.036	0.229 ± 0.013	0.062 ± 0.012
muscle	0.507 ± 0.077	0.536 ± 0.074	0.199 ± 0.050
fat	0.723 ± 0.193	1.018 ± 0.284	1.034 ± 0.144
brain	0.436 ± 0.038	0.341 ± 0.035	0.040 ± 0.004
thyroida	0.154 ± 0.057	0.339 ± 0.096	3.784 ± 0.647
heart:blood	28.94 ± 3.61	22.35 ± 3.83	9.737 ± 2.239
heart:lung	10.68 ± 1.34	9.316 ± 1.978	6.118 ± 1.716
heart:liver	2.402 ± 0.209	2.570 ± 0.334	2.284 ± 0.310

Male Sprague-Dawley rats (∼200 grams) were injected iv with 15-20 μCi of Z-[¹²⁵I]iodorotenone in 10% ethanol saline.

Tissue distribution values are given as percent injected dose / gram and presented as mean ± standard deviation.

^aThyroid values are given as percent injected dose/ organ.