Table 2.
Crude effect estimatesa for tibia and patella lead on MRS metabolite ratios in the hippocampus.
| Metabolite | Effect estimate | 95% CI | p-Value |
|---|---|---|---|
| Patella lead | |||
| mI/Cr | 0.04 | 0.00 to 0.08 | 0.03 |
| NAA/Cr | 0.00 | −0.05 to 0.05 | 0.99 |
| Cho/Cr | −0.01 | −0.04 to 0.02 | 0.42 |
| Tibia lead | |||
| mI/Cr | 0.04 | 0.00 to 0.08 | 0.06 |
| NAA/Cr | 0.00 | −0.05 to 0.06 | 0.90 |
| Cho/Cr | −0.01 | −0.04 to 0.03 | 0.66 |
a
Effect estimates were per 20 and 15 μg/g increases in patella and tibia lead concentration, respectively, which are the interquartile ranges for those measures in the parent Normative Aging Study population from which the subjects in this study were selected. Because of missing metabolite values the number of subjects in analyses of mI/Cr is 29.