Skip to main content
. 2007 Mar 8;80(4):716–726. doi: 10.1086/513206

Table 2. .

Testing SNPs for Their Ability to Explain the Admixture Association[Note]

ANOVA
Association at SNP
 AdmixtureAssociationNot Explainedby SNP
SNP Position on Chromosome 1a SNP-Specific LOD Score χ2 P χ2 P Percentage of
Locus-Specific
IL-6 SR Association
Explained by
SNP Genotype Alone
rs11582424 151177058 −.9 3 .27 38 7.7×10−10 7
rs11265608 151177213 −.7 .2 .90 39 5.0×10−10 0
rs952146 151182001 −.9 .8 .67 38 7.4×10−10 2
rs4845615 151188350 −.6 .8 .66 41 1.7×10−10 1
rs1552481 151189426 −.5 1 .61 46 1.4×10−11 3
rs4845617 151190971 −.9 4 .13 38 6.9×10−10 10
rs1386821 151195122 −.3 6 .047 37 9.2×10−10 15
rs4845618 151213088 8.6 79 ≪1.0×10−12 34 6.1×10−9 72
rs7549250 151217409 5.6 59 ≪1.0×10−12 39 4.5×10−10 63
rs7518199 151220492 11.0 114 ≪1.0×10−12 21 4.0×10−6 86
rs4845623 151228850 10.9 50 1.1×10−11 58 ≪1.0×10−12 49
rs4845625 151235140 8.8 48 3.9×10−11 51 1.1×10−12 51
rs8192284 151240043 13.6 195 ≪1.0×10−12 2 .13 99
rs11265618 151243165 .6 13 .0015 36 2.1×10−9 27
rs4329505 151245493 −.8 2 .29 37 1.3×10−9 6
rs7526293 151257282 1.8 34 3.8×10−8 25 4.6×10−7 59
rs12568083 151269022 1.0 66 ≪1.0×10−12 5 .025 93
rs4845632 151272005 .0 24 5.2×10−6 23 1.3×10−6 52
rs12740969 151300133 3.6 63 ≪1.0×10−12 3 .071 95

Note.— We used a look-up table to convert χ2 statistics to P values: 2 df for the test of genotype association and 1 df for the test for admixture association beyond genotype. We do not present exact P values when P≪1.0×10-12, since it is not clear that the statistics follow an exact χ2 distribution at such extremely significant values. There is no evidence of an ancestry association beyond rs8192284. The SNP genotype explains 99% of the association evidence at the locus, and the P value for additional admixture association not explained by the SNP is .13. All tests reported in this table were uncorrected for covariates.