Table 1. .
Ratios of Missense to Synonymous SNPs and Substitutions
|
Na/Ns |
(Na/Ns)/(N0a/N0s) |
||||||||
| Data Set | Description of Data Set | No. of Genes | Theoretical N0a/N0s |
Singletons | SNPs with MAF > 25% | Substitutions in Human Lineage | Singletonsa | SNPs with MAF > 25%a | Substitutions in Human Lineagea |
| CCDS | Genomewide | 14,095 | 2.232 | … | … | .60 | … | … | .266 ± .002 |
| Obesity-related genes | 757 Individuals sequenced | 37 | 2.204 | 1.49 | … | .44 | .68 ± .02 | … | .20 ± .05 |
| NIEHS-EGP | 90–95 Individuals sequenced | 518 | 2.255 | 1.36 | .56 | .50 | .61 ± .02 | .26 ± .04 | .22 ± .01 |
| SeattleSNPs | 46–47 Individuals sequenced | 236 | 2.203 | 1.43 | .66 | .66 | .65 ± .04 | .32 ± .05 | .30 ± .02 |
| JSNP | 750 Individuals genotyped | 8,786 | 2.244 | 1.37b | .54 | .54 | .61 | .24 | .24 |
a
Data are mean ± SE.
b
SNPs with observed frequency <1% instead of singletons have been used in analysis of the JSNP data set.