Figure 3. .

Mapping of a locus for Crisponi syndrome on 19p12-13.1. Multipoint linkage analysis was performed using 250K SNP genotype data from nine affected and three unaffected children. The program MERLIN was used with the recently implemented LD-modeling option, to avoid inflated LOD scores.¹³ A, Under the assumption of locus heterogeneity (i.e., HLOD calculation), the highest LOD scores were obtained for chromosome 19 markers, with a maximum LOD score of 4.74 at 46.77 cM, according to the deCODE map. B, Magnification of chromosome 19. The red line indicates the position of the CRLF1 gene.