Figure 4. .

Haplotype analyses on chromosome 19p12-13.1. Homozygous regions that are supposed to be identical by descent in each family are shown in red. The position of the CRLF1 gene is indicated by a boxed SNP trio representing an intragenic SNP (rs8107912) and the two nearest flanking SNPs (rs7258589 and rs7256751) that are tiled on the 250K Sty array from Affymetrix. A critical interval of 1.45 Mb may be defined by the overlap of homozygous regions (solid arrows). The broken-line arrows define less reliable borders if it is decided beforehand that either F1 or F2 is homozygous at the disease-gene locus.