Table 1. .
Characteristics of the Study Population
| All |
MTHFR 677C→T Genotype(Median [1st–99th Percentile]) |
|||||
| Characteristic | Mean | Median (1st–99th Percentile) | CC (n=5,452) |
CT (n=4,299) |
TT (n=850) |
P for trend |
| Age, years | 56 | 55 (50–64) | 55 (50–64) | 55 (50–64) | 55 (50–64) | .11 |
| Plasma tHcy, μmol/liter | 10.8 | 10.2 (5.8–24.2) | 9.9 (5.7–19.2) | 10.4 (5.9–22.8) | 11.2 (5.7–43.3) | <.001 |
| Serum folate, nmol/liter | 17.1 | 13.7 (4.7–59.8) | 14.5 (5.2–60.8) | 13.4 (4.8–59.9) | 10.5 (3.5–50.1) | <.001 |
| Plasma riboflavin, nmol/liter | 18.1 | 10.4 (3.0–135) | 10.4 (3.0–150) | 10.4 (2.8–135) | 10.7 (2.8–119) | .06 |
| Serum cobalamin, pmol/liter | 331 | 307 (128–732) | 308 (127–734) | 308 (130–730) | 300 (113–766) | .19 |
| Plasma vitamin B6, nmol/liter | 62.8 | 48.0 (12.7–295) | 47.9 (13.3–280) | 49.0 (12.6–336) | 44.4 (11.9–286) | .34 |
| Plasma creatinine, μmol/liter | 70 | 69 (44–105) | 69 (44–106) | 70 (45–104) | 66 (45–101) | .01 |