FIGURE 3.

The position of the edited site in the α3 subunit and evolutionary conservation. (A) The protein sequence of Gabra-3 consists of four transmembrane domains (TM1–TM4). The edited site was located within TM3 at amino acid 5 (of 22). (B) The I/M sites of Gabra-3 in frog (Xenopus tropicalis) and pufferfish (Tetraodon nigroviridis) have a genomically encoded methionine where all other organisms have an isoleucine (Hinrichs et al. 2006). (C) An evolutionary tree showing the phylogenetic relationship between the species in B (Meyer and Zardoya 2003; Kriegs et al. 2006).