Table 1.
Genes regulated by PHR domain in vivo
| Affy ID | Gene description | Ratio |
|---|---|---|
| Downregulated in ΔPHR liver | ||
| 1416632_at | Malic enzyme, supernatant | 5.20 |
| 1430307_a_at | Malic enzyme, supernatant | 3.72 |
| 1422479_at | Acetyl-coenzyme A synthetase 2 (ADP forming) | 3.26 |
| 1425326_at | ATP citrate lyase | 2.80 |
| 1450970_at | Glutamate oxaloacetate transaminase 1, soluble | 2.78 |
| 1422478_a_at | Acetyl-coenzyme A synthetase 2 (ADP forming) | 2.72 |
| 1434216_a_at | DNA segment, Chr 7, Roswell Park 2 complex, expressed | 2.35 |
| Upregulated in ΔPHR liver | ||
| 1435716_x_at | Small nuclear ribonucleoprotein N | 0.44 |
| 1449109_at | Suppressor of cytokine signaling 2 | 0.41 |
| 1438676_at | Expressed sequence AI595338 | 0.35 |
| 1436058_at | Mus musculus transcribed sequences | 0.35 |
| 1424126_at | Aminolevulinic acid synthase 1 | 0.35 |
| 1449009_at | T-cell specific GTPase | 0.34 |
| 1416443_a_at | Ubiquitin-like 1 (sentrin) activating enzyme E1A | 0.34 |
| 1418837_at | RIKEN cDNA 2410027J01 gene | 0.30 |
| 1449793_at | AV329014 RIKEN | 0.29 |
| 1417185_at | Lymphocyte antigen 6 complex, locus A | 0.29 |
| 1420835_at | RIKEN cDNA 4933433D23 gene | 0.29 |
| 1425127_at | Hydroxysteroid dehydrogenase-2, delta<5>-3-beta | 0.26 |
| 1448724_at | Cytokine inducible SH2-containing protein | 0.25 |
| 1425120_x_at | RIKEN cDNA 2310061N23 gene | 0.24 |
| 1428022_at | cDNA sequence BC027556 | 0.21 |
| 1456212_x_at | BB831725 RIKEN | 0.19 |
| 1450018_s_at | RIKEN cDNA 4933433D23 gene | 0.19 |
| 1418835_at | Pleckstrin homology-like domain, family A, member 1 | 0.17 |
| 1420836_at | RIKEN cDNA 4933433D23 gene | 0.17 |
| 1423696_a_at | RIKEN cDNA 2400006A19 gene | 0.10 |
| 1434496_at | Cytokine inducible kinase | 0.08 |
| 1425394_at | cDNA sequence BC023105 | 0.07 |
| 1418086_at | Protein phosphatase 1, regulatory (inhibitor) subunit 14A | 0.06 |
| Affymetrix M430A arrays were used to analyze total liver RNA from two wild-type and two ΔPHR mice (fed state). Genes consistently up- or downregulated in the ΔPHR (i.e. two-fold change in all +/+ versus ΔPHR pairwise comparisons), and which were scored as ‘present' or ‘marginally present' in both of the samples with the highest expression are shown. Ratio indicates the ratio of normalized values (+/+/ΔPHR). | ||