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Domain architecture of the Hsp70 superfamily. The relative arrangement of the nucleotide-binding domain ([NBD]; shown binding adenosine triphosphate [ATP]) and the peptide-binding domain (PBD), composed of the β sandwich and α helical lid subdomains, is indicated. At left are shown the yeast and generic names for the three major Hsp70 subfamilies. The typical Hsp70 also is referred to as the DnaK type, in reference to the sole bacterial Hsp70-type chaperone
