Table 4.
Traditional risk factors distribution according to MTHFR polymorphism and CAD. 677CC, 677CT, and 667TT are the wild-type, the heterozygous, and the mutant genotypes. Comparison of traditional risk factors between MTHFR genotypes (chi-square test), in cases and controls separately (P1) and in all subjects (P2).
| Total population | MTHFR polymorphism | P1 | P2 | |||
| 677CC | 677CT | 677TT | ||||
| Number of subjects | 400 | 214 | 139 | 47 | — | — |
| Male gender, n (%) | — | — | — | — | — | 0.302 |
| Case | 126 (31.5) | 62 (29.0) | 47 (33.8) | 17 (36.2) | 0.81 | — |
| Control | 92 (23.0) | 55 (25.7) | 27 (19.4) | 10 (21.3) | 0.43 | — |
| Smoking yes, n (%) | — | — | — | — | — | 0.023 |
| Case | 77 (19.3) | 41 (19.2) | 29 (20.9) | 7 (14.9) | 0.19 | — |
| Control | 31 (7.8) | 15 (7.0) | 7 (5.0) | 9 (19.1) | 0.000 | — |
| Hypertension yes, n (%) | — | — | — | — | — | 0.317 |
| Case | 91 (22.8) | 51 (23.8) | 30 (21.6) | 10 (21.3) | 0.11 | — |
| Control | 55 (13.8) | 39 (18.2) | 13 (9.4) | 5 (6.4) | 0.12 | — |
| Diabetes yes, n (%) | — | — | — | — | — | 0.242 |
| Case | 59 (14.8) | 29 (13.6) | 24 (17.3) | 6 (12.8) | 0.48 | — |
| Control | 34 (8.5) | 22 (10.3) | 10 (7.2) | 2 (4.3) | 0.74 | — |
| Obesity yes, n (%) | — | — | — | — | — | 0.852 |
| Case | 53 (13.3) | 42 (19.6) | 10 (7.2) | 1 (2.1) | 0.000 | — |
| Control | 31 (7.8) | 17 (7.9) | 12 (8.6) | 2 (4.3) | 0.67 | — |
| Dyslipidemia yes, n (%) | — | — | — | — | — | 0.427 |
| Case | 65 (16.3) | 39 (18.2) | 24 (17.3) | 2 (4.3) | 0.003 | — |
| Control | 39 (9.8) | 20 (9.3) | 15 (10.8) | 4 (8.5) | 0.51 | — |