Table 5.

OR (95% CI) of CAD associated to the studied risk factors according to MTHFR C677T polymorphism. OR: odds ratio; 95% CI: 95% confidence interval; CAD: coronary artery disease; MTHFR: methylenetetrahydrofolate reductase; P: significant value.

	Methylenetetrahydrofolate reductase C677T genotype
	677CC	P	677CT	P	677TT	P
Number of subjects	214	—	139	—	47	—
Sex	1.68 (0.97–2.89)	0.063	1.91 (0.97–3.76)	0.062	0.73 (0.21–2.51)	0.615
Smoking habits	4.46 (2.28–8.75)	0.000	4.57 (1.84–11.36)	0.001	0.23 (0.06–0.83)	0.025
Hypertension	1.94 (1.12–3.35)	0.019	2.31 (1.08–4.95)	0.032	2.06 (0.48–8.92)	0.332
Diabetes	1.67 (0.88–3.14)	0.115	2.27 (0.99–5.20)	0.054	1.68 (0.30–9.47)	0.556
Obesity	4.02 (2.10–7.70)	0.000	0.60 (0.24–1.50)	0.275	0.23 (0.02–2.79)	0.251
Dyslipidemia	2.93 (1.56–5.49)	0.001	1.36 (0.64–2.90)	0.422	0.21 (0.03–1.28)	0.091
Hyperhomocysteinaemia	2.47 (1.31–4.65)	0.005	4.31 (2.02–9.19)	0.000	8.68 (2.05–36.69)	0.003