Table 3.

Expression of p27^Kip1, MIB1, and p53 in 10 Cases of Blastic Variant of MCL

Case	Diagnosis	p27*	MiB1	p53
1	MCL-blastic	−	83%	20%
2	MCL-blastic	−	80%	20%
3	MCL-blastic	+	70%	>80%
4	MCL-blastic	++	100%	20%
5	MCL-blastic	+	50%	>80%
6	MCL-blastic	+	95%	<5%
7	MCL-blastic	+	76%	0%†
8	MCL-blastic	+	32%	50%
9	MCL-blastic	+	50%	>80%
10	MCL-blastic	+	48%	0%‡

*+, most tumor cells faintly positive and less intense than T lymphocytes; ++, most tumor cells positive with equal intensity as T lymphocytes.

^†In this case a homozygous deletion of p16 was detected by Southern blot.

^‡In this case a hemizygous deletion of p16 was detected by cytogenetic analysis:del (9) (p12).