Figure 6.

Hepatocytic biochemical function of DPPIV⁺-transplanted cells in DPPIV⁻ mutant rat liver. A through D: Serial sections of liver 30 days after transplantation of 2 × 10 6 DPPIV⁺ hepatocytes, showing expression of (A) DPPIV, (B) albumin, (C) glycogen, and (D) cytokeratin-19. E and F: Separate serial sections showing (E) DPPIV and (F) glucose-6-phosphatase, another protein expressed uniquely in hepatocytes. Transplanted cells show expression of albumin, glycogen, and glucose-6-phosphatase at levels at least as high as in endogenous hepatocytes. At earlier time points, the expression of these proteins is substantially higher than in the surrounding liver. Original magnification: A through F, ×100.