Table 2.
Immunohistochemical Identification of sst2A Receptors in Cryostat Sections of Selected Tumors and Comparison with Receptor Autoradiography and in Situ Hybridization
| Tumor number | Tumor type | Immunohisto- chemistry R2-88 | Receptor autoradiography | In situ hybridization, sst mRNA | |
|---|---|---|---|---|---|
| OCT-R | SS-28-R | ||||
| SS-R positive (sst2) | |||||
| 1 | Intestinal carcinoid | + | + | + | sst2+ |
| 2 | Intestinal carcinoid | + | + | + | NT |
| 3 | Bronchial carcinoid | + | + | + | sst2+ |
| 4 | Ileal carcinoid | + | + | + | NT |
| 5 | GH-secreting pituitary adenoma | + | + | + | sst2+ |
| 6 | GH-secreting pituitary adenoma | + | + | + | NT |
| 7 | Invasive lobular breast carcinoma | + | + | + | sst2+ |
| 8 | Moderately differentiated invasive ductal breast carcinoma | + | + | NT | NT |
| 9 | Meningioma, meningothelial | + | + | + | sst2+ |
| 10 | Hemangiopericytoma, tight | + | + | + | sst2+ |
| 11 | Medulloblastoma | + | + | + | sst2+ |
| 12 | Paraganglioma | + | + | + | NT |
| 13 | Lymphoma, Hodgkin’s disease, mixed cellularity | + | + | NT | NT |
| SS-R positive (sst2 negative) | |||||
| 14 | Bronchial carcinoid | − | − | + | sst1+ |
| 15 | Leiomyosarcoma, small intestine | − | − | + | sst1+ |
| SS-R negative | |||||
| 16 | Intestinal carcinoid | − | − | − | NT |
| 17 | Bronchial carcinoid | − | − | − | NT |
| 18 | Bronchial carcinoid | − | − | − | NT |
| 19 | Intestinal carcinoid | − | − | − | sst2− |
| 20 | Nonfunctioning pituitary adenoma | − | − | − | NT |
| 21 | Moderately differentiated invasive comedo carcinoma of the breast | − | − | − | NT |
| 22 | Leiomyosarcoma, abdomen | − | − | − | sst2− |
| 23 | Moderately differentiated colon adenocarcinoma | − | − | − | NT |
| 24 | Moderately differentiated squamous cell carcinoma of the esophagus | − | − | − | NT |
OCT-R, receptor autoradiography using 125I-labeled Tyr3-octreotide; SS-28-R, receptor autoradiography using 125I-labeled LTT-SS-28; NT, not tested; SS-R, somatostatin receptors.