Table 2.
Relationship between the Level of p27Kip1 Protein in Primary and Metastatic Melanoma from the Same Patient
| p27Kip1 protein level* | ||||
|---|---|---|---|---|
| Metastasis | Primary tumor† | |||
| − | + | ++ | +++ | |
| − | 2‡ | 5 | 2 | 3 |
| + | 2 | 2 | 0 | 1 |
| ++ | 1 | 2 | 3 | 3 |
| +++ | 1 | 0 | 1 | 1 |
*Measured as described in Materials and Methods.
†In 29 cases, primary and metastatic tumor from the same patient could be analyzed.
‡In eight cases with the same proportion of cells stained in the primary and metastatic tumor, a lower staining intensity was found in four of the metastases.