Table 3.
Relationship between p27Kip1 Levels and Depth of Tumor Growth of Primary Melanomas
Tumor type | Immunohisto- chemistry* | Number of patients | Depth of growth† (mm) |
---|---|---|---|
Superficial | High | 24 | 1.15 P = 0.56 |
Low | 55 | 1.15 | |
Nodular | High | 13 | 2.30 P = 0.05 |
Low | 21 | 5.20 |
*Scored as described in Materials and Methods: <50% cells stained, low expression; >50% cells stained, high expression. Changing the cutoff to high when more than 50% of the cells were p27 positive did not alter the outcome. A total of 113 tumors were analyzed.
†Measured as the median thickness in each group.