Table 2.
Sequence of Pathological Changes in the Mouse Thalamus after TD
| Alterations | Control (n = 4) | TD, 9 days (n = 4) | TD, 10 days (n = 4) | TD, 11 days (n = 4) |
|---|---|---|---|---|
| IgG extravasation* | −−−− | −−−− | ++++ | ++++ |
| NADPH-d staining of microvessels† | −−−− | −−−− | ++++ | ++++ |
| Ferritin-positive activated microglia | −−−− | −−−− | ++++ | ++++ |
| Iron deposition in activated microglia | −−−− | −−−− | ++++ | ++++ |
| eNOS staining of microvessels | −−−− | −−−− | ++−+ | ++++ |
| iNOS staining of macrophage | −−−− | −−−− | −+−+ | ++++ |
| Nitrotyrosine staining of axons | −−−− | −−−− | ++++ | ++++ |
| Cell loss‡ | −−−− | −−−− | −−−+ | ++++ |
eNOS, endothelial NOS; iNOS, inducible NOS. Data represent the presence (+) or absence (−) of the abnormality in each animal.
*Region-specific increase in IgG immunoreactivity.
†Intense NADPH-d reactivity of microvessel walls compared with controls.
‡Measured by the presence of areas of cell death in βPP-stained sections.