Figure 2.

The effect of B-cell (A) or CD8+ T-cell (B) depletion on the development of human lymphocyte infiltration of allogeneic skin grafts in SCID mice. Skin grafts were harvested between days 16 and 21 after i.p. injection of human PBMCs, and then H&E-stained specimens were scored for the degree of mononuclear cell infiltration as described in Materials and Methods. The mean score of mock-treated versus other groups was different (P < 0.05 by analysis of variance). No difference was apparent between either depletion group and the whole-PBMC group (P > 0.05 by analysis of variance).