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. 1998 Sep;153(3):921–930. doi: 10.1016/S0002-9440(10)65633-7

Figure 5.

Figure 5.

Effect of dexamethasone treatment on the IL-8 production by cultured ΔF508 homozygous CF and non-CF HBG cells. IL-8 levels were measured in 6-hour supernatants from CF and non-CF HBG cell cultures after addition of dexamethasone at final concentrations of 1, 5, and 10 μmol/L, respectively. Data are expressed as a percentage of IL-8 recovered 6-hour after dexamethasone addition by comparison to values obtained from untreated CF and non-CF HBG cell cultures (control, 100%), respectively. Interestingly, dexamethasone treatment significantly (P < 0.001) blocks the IL-8 release of non-CF HBG cells but, in contrast, failed to block the IL-8 release of CF HBG cells, even when levels were increased to 5 μmol/L. Data represent means ± SD of eight CF HBG cell cultures and four non-CF HBG cell cultures, each assayed in triplicate. **P < 0.01; ***P < 0.001.