Table 1.
Time Course of Pathology in Tg6074 Mouse Brain
| Age | Mice (n) | Inflammation | Vacuolation | SFD | Plaques | Oligodendrocyte apoptosis | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Meninges | Parenchyma | CER | CI | CER | CI | CER | CI | |||
| 1 | 2 | − | − | − | − | − | − | − | − | + |
| 2 | 2 | + | +/− | − | − | − | − | − | − | + |
| 4 | 2 | + | + | + | + | + | + | − | − | + |
| 5 | 2 | + | + | + | + | + | + | − | − | + |
| 6.5 | 2 | + | + | + | + | + | + | + | − | + |
| 8 | 4 | + | + | + | + | + | + | + | +* | + |
| 10 | 4 | + | + | + | + | + | + | + | + | + |
Age: weeks after birth. Inflammation: presence of mononuclear cells in meninges and parenchyma. Vacuolation: presence of vacuolation in cerebellum (CER) or capsula interna (CI). SFD, single fiber degeneration as determined by LFB staining or PLP immunostaining; Plaques, presence of confluent demyelinated lesions in cerebellum or capsula interna. Oligodendrocyte apoptosis: presence of CNP-positive apoptotic cells.
−, not present; +, present; +/−, some mononuclear cells present in 1 of 2 animals.
*2 of 4 animals showed confluent lesions in the CI.