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Myelin Pathology in the Cerebellum of Tg6074 Transgenic Mice
| Age (wk) | Mice (n) | Myelin | ||
|---|---|---|---|---|
| Normal (%) | Vacuolation (%) | Demyelination (%) | ||
| 4–6 | 4 | 60 ± 5.2 | 40 ± 5.2 | 0 |
| 6–8 | 6 | 23 ± 5.1 | 27 ± 10.2 | 50 ± 9.9 |
| 10 | 4 | 18 ± 3.3 | 30 ± 17.0 | 53 ± 19.0 |
The total area of cerebellar white matter (average, 0.5 mm2) and the relative proportions (% with SEM) of demyelinated (confluent) and vacuolated areas were determined using an ocular morphometric grid.
