Table 3.
Time Course and Extent of Pathology in TgK21 Mouse Spinal Cord
| Age | Mice (n) | Inflammation | Oligodendrocyte apoptosis | Myelin | ||
|---|---|---|---|---|---|---|
| Meninges | Parenchyma | Normal (%) | Demyelination (%) | |||
| 1 | 2 | + | − | − | 100 | 0 |
| 2 | 2 | + | − | − | 100 | 0 |
| 3 | 3 | + | +/− | + | 100 | 0 |
| 4 | 3 | + | + | + | 67± 8 | 33± 15 |
Age: weeks after birth. Inflammation: presence of mononuclear cells in meninges and parenchyma. Oligodendrocyte apoptosis: presence of CNP-positive apoptotic cells.
−, not present; +, present. The total area of spinal cord white matter (average, 0.5 mm2) and the relative proportions (% with SEM) of demyelinated (confluent) areas were determined using an ocular morphometric grid.