Table 5.
Summary of p16/INK4A Genetic Alteration Findings in the Group with Loss of p16/INK4A Protein Expression
Number | Diagnosis | p16 protein expression* | Gene status† | Allelic loss at 9p21 | Methylation in exon 1§ |
---|---|---|---|---|---|
L174 | MALT+ DLBCL | −/+ | wt | met + | |
L139 | MALT+ DLBCL | − | wt | ND | met+ |
MT51 | MALT + DLBCL | − | wt | LOH | met+ |
MT53 | MALT+ DLBCL | − | wt | LOH | |
L198 | MALT+ DLBCL | − | wt | ||
L182 | FL+ DLBCL | − | wt | ||
LF4 | FL+ DLBCL | − | wt | LOH | |
L168 | FL+ DLBCL | − | wt | ND | |
L173 | Nodal DLBCL | − | wt | met+ | |
L169 | Nodal DLBCL | − | wt | ND | met+ |
BK13 | Burkitt’s lymphoma | −/+ | wt | ND | |
BK20 | Burkitt’s lymphoma | −/+ | Mut | ND | |
BK21 | Burkitt’s lymphoma | −/+ | wt | met+ |
*p16 protein expression: −/+, partial loss; −, diffuse loss.
†wt, wild type; Mut, mutation.
§met +, existence of CpG methylation; ND, not done.