Table 1.

Immunohistochemical Analysis of p27 Protein Expression in Primary Tumor-Metachronous Metastases Pairs

Patient no.	Stage	Chemotherapy	Interval to metastases (months)	p27 level (%)
				in primary tumor	in metastases
1	III	+	35	67	3
2	III	−	36	60	2
3	III	+	60	0	7
4	I	−	35	38	13
5	II	+	36	17	32
6	II	+	18	54	28
7	II	+	21	0	0
8	III	+	17	63	7
9	II	+	19	48	11
10	II	−	6	69	26
11	III	+	21	67	34
12	III	+	20	18	14
13	III	+	27	41	11
Mean ± SEM				41.7± 7.0	14.5± 3.2 (p = 0.0023)