Table 3.
Migration of MBP-Specific T Cells into the CNS
| Time point | Parenchyma | Meninges and perivascular space | ||||
|---|---|---|---|---|---|---|
| Average MBP T cells | Total T cells | % of total T cells | Average MBP T cells | Total T cells | % of total T cells | |
| 2 hours (n = 3) | 1.3 ± 0.9 | 1.0 ± 0.6 | ND | 0 | 0 | ND |
| Day 1 (n = 6) | 0.5 ± 0.5 | 3.0 ± 0.7 | ND | 0 | 0 | ND |
| Day 4 (n = 4) | 233 ± 64 | 475 ± 117 | 48 ± 9.3 | 92 ± 21 | 415 ± 58 | 25 ± 9.1 |
| Day 6 (n = 8) | 116 ± 32 | 471 ± 57 | 23 ± 5.7 | 16 ± 7.8 | 227 ± 36 | 11 ± 3.3 |
| Day 9 (n = 5) | 14 ± 4.6 | 84 ± 30 | 24 ± 7.8 | 1.2 ± 0.37 | 59 ± 10.1 | 1.9 ± 0.5 |
The average number of TK-tsA+ MBP-specific T cells/spinal cord cross-section (parenchyma or meninges and perivascular space) is given ± SEM. The number of T cells was quantified in consecutive W3/13-stained sections. ND, not determined.