Figure 2.

Relationship between weak and strong p53 and p21^WAF-1/CIP1 expression and apoptosis. Shown is the subdivision of the p53-positive cell population into weakly/moderately immunoreactive (shaded line) and strongly immunoreactive (solid, bold line) groups. Also shown are the distribution of apoptotic cells (solid, fine line) and p21^WAF-1/CIP1-positive cells (dashed line). Data are for the 4-hour time point after exposure of BDF-1 mice to 8 Gy γ-radiation. Data are mean results from a minimum of three mice at each time point. At least 1000 cells (50 half-crypts) were scored from each mouse. The data are from one representative experiment typical of three.