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In situ hybridization of MT2-MMP mRNA in normal liver (A), cholestatic liver (B and C), HCCs (E and F), and metastasis from a colonic adenocarcinoma (G). Control with sense probe in situ hybridization is shown (D, section contiguous to C). bd, bile duct; star, tumor. Bright-field (A, B, and D to G) and dark-field (C) photomicrographs of autoradiographs stained with hematoxylin and eosin. Magnification: A, B, and E to G, ×400; C and D, ×200.
