Table 3.
IL-10 and EBER mRNA expression in NK-Cell Lymphomas: Correlation with Cytotoxic Protein Expression by Immunohistochemistry
| Cases | Age/Sex | Histology Kiel/REAL | Site of biopsy | Other sites of involvement | IL-10 mRNA expression (positive cells/mm2) | TIA-1 | Granzyme B | EBER | Outcome |
|---|---|---|---|---|---|---|---|---|---|
| 40 | 28 /F | PML/AL | Nasal | I | 3.6 | +++ | +++ | +++ | NA |
| 41 | 83 /M | PML/AL | Nasal | I | 1.4 | +++ | +++ | +++ | DOD, 27 months |
| 42 | NA | PML/AL | Nasal | NA | 11.1 | +++ | +++ | +++ | CR, alive (36 months) |
| 43 | 35 /F | PML/AL | Nasal | I | 198.6 | +++ | +++ | +++ | DOD, 9 months |
| 44 | 25 /M | PML/AL | Nasal | I | 165.0 | +++ | +++ | +++ | CR after local relapse |
| 45 | 58 /M | PML/AL | Nasal | I | 34.7 | +++ | +++ | +++ | DOD, 4 months |
| 46 | 43 /F | PML/AL | Nasal | I | 2.8 | +++ | +++ | +++ | DOD, 15 months |
For IL-10, the number of positive cells was estimated per mm 2 of tissue sections. For TIA-1, granzyme B, and EBER, the results are expressed as in Table 1 ▶ . Abbreviations: REAL, Revised European-American Lymphoma classification; AL, angiocentric lymphoma; M, male; F, female; AWD, alive without disease; DOD, dead of disease; and CR, complete remission.