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. 1998 Oct;153(4):1201–1209. doi: 10.1016/S0002-9440(10)65664-7

Figure 3.

Figure 3.

Examples of K-ras2 mutation spectrum analysis. K-ras2 mutation analysis was for wild type in codons 12 and 13 (wild-type codon 12 GGT-gly and codon 13 GGC-gly), six possible mutations in codon 12 (AGT, TGT, CGT, GAT, GCT, and GTT), and two mutations in codon 13 (AGC and GAC). K-ras2 wild-type controls were the following: peripheral blood lymphocytes of healthy donors (g6), SW837 cell line with heterozygous TGT mutation (h2), NIH3T3 cell line with transfected CGT human mutated K-ras2 (h3), SW480 cell line with homozygous GTT mutation (h4), and DLD-1 cell line with heterozygous GAC mutation (h5). All other spots correspond to different wild-type or mutated adenoma samples. Of particular interest are adenomas with TGT mutation in both diploid and aneuploid subclones (e2 and e3) and adenomas with GTT (a6 and b1) and GAT (c2 and c3) mutations in both low-grade and high-grade dysplasia components.