Photomicrographs of serial sections of the hippocampus from an AD patient (A–C), a patient with Guamanian Parkinson-dementia complex (D–F), and a control subject (G–I). Both I-NFTs (arrows) and E-NFTs (arrowheads) are strongly labeled by anti-tau protein antibody (A, D, and G). I-NFTs show definite AGE immunoreactivity (arrows), whereas E-NFTs are virtually negative (arrowheads, B, E, and H). E-NFTs show strong ApoE immunoreactivity (arrowheads), but I-NFTs are negative (arrows, C, F, and I). Magnification, ×380.