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. 2007 Mar 30;7:4. doi: 10.1186/1472-6793-7-4

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Copyright © 2007 Saban et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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A-B. Comparison of the inflammatory responses (PMNs infiltration) obtained with wild type (C57BL/6J), PAR1^-/-, and PAR2^-/-mice. Responses were obtained 24 hours after bladder instillation with one of the listed substances. Figure 7A represents the response to substance P (10μM), Escherichia coli LPS strain 055:B5 (100 μg/ml), and DNP4-OVA (in sensitized mice; 1 μg/ml) compared to saline (black bars). Figure 7B represents the responses to PAR1-AP (10 μM) and PAR2-AP (10 μM) compared to control inactive peptide (10 μM). Number of mice = 6–8 per group. NS= not significant. Asterisks represent a statistically significant difference (p < 0.05) between the responses obtained with each pro-inflammatory stimuli in PAR1^-/-or PAR2^-/-and the respective response obtained in wild type mice.