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. Author manuscript; available in PMC: 2008 Mar 1.
Published in final edited form as: Exp Neurol. 2006 Oct 27;204(1):77–87. doi: 10.1016/j.expneurol.2006.09.018

Figure 2.

Figure 2

Defective neurogenesis in the APP/PS-1 double knock-in mutant mouse hippocampus persists during aging. Sagittal sections from 18–20 month old mice of the indicated genotypes immunostained for doublecortin. With aging, there is a reduction in the number of developing neurons in the subgranular zone when compared with the 8–9 month age. As seen for the earlier age, the APP knock-in mutation does not affect neuroblast number and the PS-1 knock-in mutation causes only a small decrease. On the other hand, the APP/PS-1 double knock-in mutation led to a large reduction in the number of developing neurons. Scale bar = 200 μm (left panels), 50 μm (right panels).