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. Author manuscript; available in PMC: 2008 Mar 1.
Published in final edited form as: Exp Neurol. 2006 Oct 27;204(1):77–87. doi: 10.1016/j.expneurol.2006.09.018

Figure 3.

Figure 3

The PS-1 knock-in mutation reduces the number of neural stem and progenitor cells in the hippocampus when combined with the APP knock-in mutation. Sagittal sections from 8–9 month old mice of the indicated genotypes immunostained for the marker of cycling cells MCM2. Cells intensely stained for this marker are found along the dentate subgranular zone. For mice homozygous for the APP Swedish knock-in mutation, the addition of one mutant PS-1 allele caused a small decrease in immunopositive neural stem and progenitor cells. Two mutant PS-1 alleles led to a further decline in these cell populations. Scale bar = 100 μm (A,B), 40 μm (C,D).