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. Author manuscript; available in PMC: 2008 Mar 1.
Published in final edited form as: Mol Cell Neurosci. 2007 Feb 2;34(3):481–492. doi: 10.1016/j.mcn.2006.12.002

Figure 10.

Figure 10

PTPμ-specific inhibitor peptide blocks neurite outgrowth on E-cadherin and N-cadherin. E8 chick retinal explants were cultured on laminin (A, B), N-cadherin (C, D), or E-cadherin (E, F) substrates for 20 hours in the presence of either scrambled control (SPTPμ-Tat) (A, C, E) or the PTPμ wedge peptide (WPTPμ-Tat) (B, D, F) at a final concentration of 5.5 μM. Cultures incubated with WPTPμ-Tat had no effect on laminin-dependent neurite outgrowth (A) when compared to SPTPμ-Tat control (B). Neurite length (G) decreased by 46% on N-cadherin and by 80% on E-cadherin substrates, while neurite density (H) decreased by 84% on N-cadherin and by 90% on E-cadherin in the presence of WPTPμ-Tat (hatched bars) when compared to SPTPμ-Tat control (white bars). Asterisk denotes statistically significant changes in neurite length or density compared to control. n = 4 for laminin, n = 5 for N-cadherin n =6 for E-cadherin. Scale bar, 200 μm.