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. Author manuscript; available in PMC: 2007 Apr 20.
Published in final edited form as: Vaccine. 2006 May 3;24(25):5381–5389. doi: 10.1016/j.vaccine.2006.04.034

Table 1.

HLA class II allelic associations with whole measles virus-specific cytokinea responses

HLA locus Number of alleles IFN-γ
IL-4
Median secretion value (Q1, Q3) pg/ml Allele p-valueb,c HLA-DR-adjusted p-valued Number of alleles Median secretion value (Q1, Q3) pg/ml Allele p-valueb,c HLA-DR-adjusted p-valued
Overall 612 66.8 (12.7, 231.9) 568 10.3 (3.9, 24.9)
HLA-DQB1
*0201 82 25.9 (8.7, 120.8) 0.02 0.61 77 8.9 (5.1, 23.9) 0.93 0.65
*0202 47 45.1 (3.4, 112.8) 0.07 0.91 44 4.9 (0.9, 21.9) 0.05 0.89
*0301 117 66.8 (13.6, 248.5) 0.55 0.16 110 10.2 (4.0, 25.6) 0.64 0.37
*0302 61 75.3 (18.6, 281.1) 0.31 0.27 55 12.2 (4.0, 32.0) 0.61 0.84
*0303 24 22.9 (0.1, 96.3) 0.02 0.45 20 7.3 (0.7, 20.9) 0.20 0.22
*0402 17 27.3 (8.3, 68.8) 0.11 0.36 15 9.7 (4.4, 33.5) 0.57 0.74
*0501 70 73.2 (14.5, 196.8) 0.93 0.99 71 14.3 (4.3, 24.8) 0.88 0.58
*0502 10 175.3 (52.9, 227.8) 0.08 0.29 7 11.1 (7.5, 17.9) 0.87 0.74
*0503 15 67.1 (18.7, 198.1) 0.96 0.93 13 8.1 (0.6, 18.5) 0.34 0.48
*0602 85 123.5 (42.6, 325.7) 0.003 0.28 77 15.5 (3.8, 25.3) 0.57 0.83
*0603 41 86.6 (12.6, 301.4) 0.46 0.82 42 12.1 (4.5, 30.5) 0.29 0.09
*0604 30 48.9 (−0.6, 224.4) 0.21 0.06 26 8.6 (4.3, 18.5) 0.47 0.63
All other allelese 13 214.7(39.5, 320.4) 0.08 0.08 11 17.7 (8.7, 30.4) 0.17 0.21
HLA-DPB1
*0101 46 49.2 (8.1, 119.1) 0.08 0.63 45 11.4 (5.9, 24.5) 0.63 0.38
*0201 74 42.3 (12.4, 172.4) 0.13 0.09 67 13.0 (4.5, 26.0) 0.57 0.55
*0301 65 54.3 (11.3, 306.7) 0.88 0.98 58 15.8 (4.7, 31.2) 0.20 0.20
*0401 233 73.6 (13.5, 231.9) 0.47 0.70 213 9.7 (2.8, 23.1) 0.42 0.22
*0402 74 113.4 (13.0, 323.5) 0.07 0.12 74 11.2 (1.4, 30.4) 0.63 0.84
*0501 18 62.8 (16.7, 246.1) 0.91 0.98 16 4.2 (0.6, 14.2) 0.11 0.06
*0601 13 257.2 (72.0, 379.0) 0.02 0.03 11 15.8 (7.3, 31.2) 0.22 0.22
*1101 11 45.1 (2.8, 112.8) 0.16 0.91 10 8.0 (1.9, 24.3) 0.57 0.76
*1301 13 27.4 (13.0, 118.0) 0.31 0.24 13 5.5 (0.1, 11.1) 0.14 0.27
*1401 11 80.8 (15.7, 275.7) 0.79 0.99 11 12.4 (1.0, 17.3) 0.83 0.74
*1501 7 45.1 (17.8, 232.4) 0.80 0.89 6 22.7 (4.7, 29.1) 0.45 0.56
*1701 7 129.6 (1.7, 217.3) 0.94 0.96 7 19.6 (1.8, 29.7) 0.49 0.34
All other allelese 40 66.6 (17.2, 215.4) 0.86 0.32 37 7.8 (4.4, 15.8) 0.42 0.60

Q1, Q3 represent the first and third quartiles, respectively.

Age-adjusted global p values are as follows: HLA-DQB1 IFN-γ, 0.001; HLA-DPB1 IFN-γ, 0.17; HLA-DQB1 IL-4, 0.58; HLA-DPB1 IL-4, 0.58. Age and HLA-DRB1-adjusted global P values are as follows: HLA-DQB1 IFN-γ, 0.33; HLA-DPB1 IFN-γ, 0.47; HLA-DQB1 IL-4, 0.75; HLA-DPB1 IL-4, 0.53. Suggestive findings (p < 0.10) are shown in bold.

a

Mean value of antigen stimulated cells minus mean value of control cells.

b

Linear regression analysis, accounting for the design variable age. Genotypes were modeled as ordinal variables with values ranging from 0 to 2, reflecting the number of copies possessed by an individual. Due to data skewness, all secretion values were rank-transformed.

c

Comparing genotype of interest to all other genotypes combined.

d

Analyses adjust for age and the HLA-DRB1*01, *02, *03, *04, *05, *06, *07, *08, and *09 alleles.

e

“Other” includes the following HLA-DQB1 alleles: *0203 (n = 2), *0304 (n = 1), *0306 (n = 2), *0601 (n = 4), *0608 (n = 1), *0609 (n = 1), *0614 (n = 2); and HLA-DPB1 alleles: *0202 (n = 4), *0901 (n = 6), *1001 (n = 6), *1601 (n = 4), *1901 (n = 4), *2001 (n = 3), *2101 (n = 1), *2301 (n = 3), *2401 (n = 1), *2601 (n = 2), *3001 (n = 1), *5001 (n = 1), *5101 (n = 1), *6301 (n = 1), *6601 (n = 2), respectively.