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. Author manuscript; available in PMC: 2007 Apr 20.
Published in final edited form as: Vaccine. 2006 May 3;24(25):5381–5389. doi: 10.1016/j.vaccine.2006.04.034

Table 2.

HLA class II allelic associations with naturally processed measles virus-derived P peptide-specific cytokinea responses

HLA locus Number of alleles IFN-γ
IL-4
Median secretion value (Q1, Q3) pg/ml Allele p-valueb,c HLA-DR-adjusted p-valued Number of alleles Median secretion value (Q1, Q3) pg/ml Allele p-valueb,c HLA-DR-adjusted p-valued
Overall 612 27.7 (1.8, 109.4) 568 −0.6 (−7.1, 6.2)
HLA-DQB1
*0201 82 29.0 (6.9, 111.8) 0.31 0.14 77 2.6 (−4.6, 10.7) 0.06 0.80
*0202 47 15.7 (−3.0, 78.6) 0.28 0.92 44 −0.7 (−7.0, 6.3) 0.69 0.58
*0301 117 23.5 (−2.9, 95.7) 0.36 0.98 110 −0.6 (−7.8, 4.9) 0.42 0.58
*0302 61 39.6 (5.7, 121.8) 0.30 0.52 55 0.8 (−6.4, 7.9) 0.41 0.81
*0303 24 27.6 (3.2, 174.8) 0.67 0.57 20 −2.3 (−9.1, 9.9) 0.80 0.44
*0402 17 23.9 (3.3, 55.5) 0.51 0.59 15 −1.4 (−8.0, 17.9) 0.85 0.52
*0501 70 46.6 (3.5, 106.8) 0.30 0.28 71 −0.9 (−7.3, 5.3) 0.60 0.24
*0502 10 74.6 (−1.6, 157.3) 0.74 0.50 7 −0.4 (−6.6, 7.8) 0.68 0.56
*0503 15 17.4 (0.7, 70.2) 0.61 0.76 13 −1.2 (−7.2, −0.2) 0.44 0.81
*0602 85 23.9 (−3.0, 122.2) 0.70 0.33 77 −0.7 (−9.3, 5.8) 0.50 0.59
*0603 41 33.5 (−5.9, 65.3) 0.20 0.17 42 −3.0 (−9.5, 2.4) 0.10 0.65
*0604 30 13.6 (−2.9, 142.1) 0.58 0.59 26 2.1 (−5.7, 11.1) 0.29 0.02
All other allelese 13 114.8 (17.6, 15.0) 0.04 0.02 11 0.8 (−16.2,15.0) 0.96 0.84
HLA-DPB1
*0101 46 26.9 (11.9, 111.8) 0.27 0.81 45 −1.2 (−8.7, 11.3) 0.82 0.46
*0201 74 32.9 (1.9, 111.8) 0.53 0.28 67 1.7 (−4.1, 11.1) 0.05 0.02
*0301 65 25.5 (3.5, 121.8) 0.78 0.81 58 −0.7 (−8.9, 7.4) 0.63 0.48
*0401 233 27.4 (−0.7, 106.8) 0.36 0.32 213 0.2 (−7.2, 6.3) 0.80 0.63
*0402 74 25 (−0.3, 114.8) 0.61 0.64 74 −1.7 (−8.5, 5.6) 0.17 0.28
*0501 18 29.9 (0.1, 106.8) 0.95 1.00 16 −2.6 (−7.8, 2.2) 0.25 0.21
*0601 13 14.6 (5.0, 50.9) 0.65 0.54 11 0.3 (−4.6, 4.6) 0.66 0.68
*1101 11 9.9 (−5.7, 29.6) 0.18 0.23 10 0.5 (−2.7, 12.4) 0.33 0.64
*1301 13 28.0 (6.6, 132.3) 0.98 0.61 13 −2.1 (−8.7, 0) 0.10 0.09
*1401 11 29.3 (−5.4, 127.2) 0.95 0.86 11 5.3 (−2.0, 13.5) 0.27 0.17
*1501 7 7.6 (−4.7, 164.2) 0.87 0.88 6 4.9 (−1.0, 17.9) 0.28 0.36
*1701 7 17.4 (0.1, 78.6) 0.97 0.75 7 −0.6 (−6.1, 6.3) 1.00 0.82
All other allelese 40 44.4 (3.2, 148.0) 0.27 0.23 37 −2.9 (−5.5, 4.7) 0.35 0.44

Q1, Q3 represent the first and third quartiles, respectively.

Age-adjusted global p values are as follows: HLA-DQB1 IFN-γ, 0.46; HLA-DPB1 IFN-γ 0.93; HLA-DQB1 IL-4, 0.70; HLA-DPB1 IL-4, 0.36. Age and HLA-DRB1-adjusted global p values are as follows: HLA-DQB1 IFN-γ, 0.18; HLA-DPB1 IFN-γ, 0.95; HLA-DQB1 IL-4, 0.49; HLA-DPB1 IL-4, 0.28. Suggestive findings (p < 0.10) are shown in bold.

a

Mean value of antigen stimulated cells minus mean value of control cells.

b

Linear regression analysis, accounting for the design variable age. Genotypes were modeled as ordinal variables with values ranging from 0 to 2, reflecting the number of copies possessed by an individual. Due to data skewness, all secretion values were rank-transformed.

c

Comparing genotype of interest to all other genotypes combined.

d

Analyses adjust for age and the HLA-DRB1*01, *02, *03, *04, *05, *06, *07, *08, and *09 alleles.

e

“Other” includes the following HLA-DQB1 alleles: *0203 (n = 2), *0304 (n = 1), *0306 (n = 2), *0601 (n = 4), *0608 (n = 1), *0609 (n = 1), *0614 (n = 2); and HLA-DPB1 alleles: *0202 (n = 4), *0901 (n = 6), *1001 (n = 6), *1601 (n = 4), *1901 (n = 4), *2001 (n = 3), *2101 (n = 1), *2301 (n = 3), *2401 (n = 1), *2601 (n = 2), *3001 (n = 1), *5001 (n = 1), *5101 (n = 1), *6301 (n = 1), *6601 (n = 2), respectively.