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. Author manuscript; available in PMC: 2007 Apr 20.
Published in final edited form as: Vaccine. 2006 May 3;24(25):5381–5389. doi: 10.1016/j.vaccine.2006.04.034

Table 3.

HLA class II allelic associations with naturally processed measles virus-derived N peptide-specific cytokinea responses

HLA locus Number of alleles IFN-γ
IL-4
Median secretion value (Q1, Q3) pg/ml Allele p-valueb,c HLA-DR-adjusted p-valued Number of alleles Median secretion value (Q1, Q3) pg/ml Allele p-valueb,c HLA-DR-adjusted p-valued
Overall 612 1.9 (−6.2, 13.0) 568 2.4 (−3.2, 9.3)
HLA-DQB1
*0201 82 2.2 (−5.4, 9.3) 0.50 0.52 77 2.3 (−1.2, 13.4) 0.36 0.15
*0202 47 −2.6 (−7.8, 14.0) 0.29 0.89 44 0.5 (−3.5, 6.8) 0.39 0.14
*0301 117 0.6 (−8.6, 14.7) 0.43 0.91 110 4.5 (−1.4, 11.3) 0.24 0.39
*0302 61 2.8 (−6.2, 10.4) 0.78 0.64 55 1.7 (−3.9, 8.8) 0.82 0.50
*0303 24 4.9 (−3.6, 13.8) 0.41 0.40 20 −0.1 (−7.5, 10.2) 0.47 0.68
*0402 17 4.2 (−2.8, 10.3) 0.43 0.88 15 1.9 (0.1, 9.0) 0.50 0.34
*0501 70 −1.3 (−6.1, 10.9) 0.45 0.44 71 2.1 (−3.1, 6.8) 0.24 0.38
*0502 10 2.1 (−7.5, 41.3) 0.62 0.69 7 −0.6 (−3.5, 9.9) 0.88 0.71
*0503 15 3.8 (−10.1, 10.2) 0.39 0.25 13 3.7 (−3.1, 12.2) 0.90 0.61
*0602 85 4.7 (−4.5, 35.2) 0.03 0.20 77 3.3 (−3.5, 9.9) 0.84 0.91
*0603 41 4.7 (−3.8, 12.8) 0.61 0.73 42 3.1 (−4.3, 6.2) 0.39 0.92
*0604 30 −2.2 (−12.3, 17.0) 0.34 0.18 26 3.8 (−2.0, 12.7) 0.62 0.17
All other allelese 13 7.6 (0.2, 71.5) 0.10 0.22 11 8.4 (−5.4, 19.2) 0.28 0.17
HLA-DPB1
*0101 46 2.5 (−4.5, 10.8) 0.92 0.64 45 1.8 (−3.3, 6.7) 0.49 0.35
*0201 74 0.3 (−9.0, 10.5) 0.20 0.19 67 4.8 (−2.4, 11.1) 0.46 0.47
*0301 65 1.8 (−5.5, 9.3) 0.31 0.18 58 4.3 (−1.8, 11.6) 0.26 0.21
*0401 233 2.3 (−5.5, 13.4) 0.75 0.99 213 2.8 (−3.1, 8.8) 0.73 0.67
*0402 74 2.9 (−6.1, 18.4) 0.32 0.23 74 3.7 (−2.1, 11.3) 0.69 0.83
*0501 18 7.5 (−4.5, 13.0) 0.50 0.63 16 −3.1 (−7.5, 1.9) 0.005 0.01
*0601 13 −4.6 (−17.6, 9.7) 0.13 0.19 11 5.2 (−0.3, 18.3) 0.31 0.32
*1101 11 0.4 (−3.9, 19.1) 0.82 0.42 10 −0.9 (−3.1, 6.8) 0.55 0.50
*1301 13 0.6 (−2.6, 14.7) 0.91 0.71 13 1.9 (−0.5, 9.4) 0.98 0.95
*1401 11 11.6 (−4.5, 28.4) 0.27 0.24 11 7.6 (1.6, 11.1) 0.27 0.15
*1501 7 9.2 (−8.2, 80.5) 0.26 0.17 6 6.9 (−1.5, 19.2) 0.30 0.38
*1701 7 4.7 (−2.5, 10.6) 0.53 0.44 7 1.9 (−6.7, 28.1) 0.64 0.62
All other allelese 40 −0.7 (−7.6, 18.0) 0.77 0.70 37 0.4 (−5.4, 6.8) 0.25 0.38

Q1, Q3 represent the first and third quartiles, respectively.

Age-adjusted global p values are as follows: HLA-DQB1 IFN-γ, 0.30; HLA-DPB1 IFN-γ 0.70; HLA-DQB1 IL-4, 0.87; HLA-DPB1 IL-4, 0.25. Age and HLA-DRB1-adjusted global p values are as follows: HLA-DQB1 IFN-γ, 0.55; HLA-DPB1 IFN-γ, 0.55; HLA-DQB1 IL-4, 0.18; HLA-DPB1 IL-4, 0.21. Suggestive findings (p < 0.10) are shown in bold.

a

Mean value of antigen stimulated cells minus mean value of control cells.

b

Linear regression analysis, accounting for the design variable age. Genotypes were modeled as ordinal variables with values ranging from 0 to 2, reflecting the number of copies possessed by an individual. Due to data skewness, all secretion values were rank-transformed.

c

Comparing genotype of interest to all other genotypes combined.

d

Analyses adjust for age and the HLA-DRB1*01, *02, *03, *04, *05, *06, *07, *08, and *09 alleles.

e

“Other” includes the following HLA-DQB1 alleles: *0203 (n = 2), *0304 (n = 1), *0306 (n = 2), *0601 (n = 4), *0608 (n = 1), *0609 (n = 1), *0614 (n = 2); and HLA-DPB1 alleles: *0202 (n = 4), *0901 (n = 6), *1001 (n = 6), *1601 (n = 4), *1901 (n = 4), *2001 (n = 3), *2101 (n = 1), *2301 (n = 3), *2401 (n = 1), *2601 (n = 2), *3001 (n = 1), *5001 (n = 1), *5101 (n = 1), *6301 (n = 1), *6601 (n = 2), respectively.