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. 1998 Nov;153(5):1323–1332. doi: 10.1016/s0002-9440(10)65716-1

Figure 8.

Figure 8.

Models for the mechanism of the Bcl-2 translocation. A: One-step model for the t(14;18) translocation. A more detailed view of the likely events in some bcl-2 translocations is shown (based on Ref. 65 ). The letters a and b are simply genetic markers to provide orientation. The x’s represent nucleotide addition of uncertain origin. In this model, an attempt at DH to JH joining fails to be completed. An unrelated break on chromosome 18 at the bcl-2 locus also fails to be rejoined and is, instead, joined to the DH and JH ends to yield the reciprocal translocation. B: Two-step model for the t(14;18) translocation. In this model, the first step involves synapsis of the JH segment to a cryptic site within the bcl-2 gene. Use of cryptic sites having only the CAC match to the optimal signal sequences have been observed (see text). After this V(D)J recombination event between two signal sequences (one of which was cryptic), the second event involves recombination of two standard recombination signals, which modifies the derivative 18 chromosome.