Table 1.
Clinicopathological Features, Karyotypes, ETV6-NTRK3 Fusion, and FISH Findings in Congenital Mesoblastic Nephromas and Congenital Fibrosarcomas
| Case | Age | Sex | Site/histology | Karyotype | ETV6-NTRK3 fusion | FISH | ||
|---|---|---|---|---|---|---|---|---|
| ETV6 region | Chr 8 | Chr 11 | ||||||
| CMN 1 | 1D | M | Kidney/Cellular | 47,XY,+11,t(12;15)(p13;q26) | Yes | Rearranged | Di | Tri |
| CMN 2 | 1D | F | Kidney/Mixed | 46,XX | Yes | Rearranged | Di | Di |
| CMN 3 | 6D | M | Kidney/Cellular | 47,XY,+11,t(12;15)(p13;q26) | Yes | Rearranged | Di | Tri |
| CMN 4 | 3D | M | Kidney/Classic | 46,XY | No | Nonrearranged | Di | Di |
| CMN 5 | 16D | F | Kidney/Mixed | ND | ND | Rearranged | Di | Di |
| CMN 6 | 1D | M | Kidney/Mixed | ND | ND | Rearranged | Tri | Di |
| CFS 1 | 23D | M | Back | 48,XY,+11,add(15)(q26),+20 | Yes | Rearranged | Di | Tri |
| CFS 2 | 3D | F | Back | 51,XX,add(5)(p15),+8,del(10)(p11.2), | Yes | Rearranged | Tri | Tri |
| +11,t(12;15)(p13;q26),+15,+17,+20 | ||||||||
| CFS 3 | 6M | M | Hand | 50,XY,+8,+8,+11,+11, | Yes | Rearranged | Tet | Tet |
| t(12;15)(p13;q26) | ||||||||
| CFS 4 | 11D | F | Neck | 49,XX,+11,t(12;15)(p13;q26), | ND | Rearranged | Di | Di |
| +del(17)(p12),+20 | ||||||||
| CFS 5a | 7D | F | Forearm | 46,XX | ND | Rearranged | Di | Di |
| CFS 5b | 1M | F | Forearm | 49,XX,+8,+11,+20 | ND | Rearranged | Tri | Tri |
CMN, congenital mesoblastic nephroma; M, male; F, female; CFS, congenital fibrosarcoma; D, day; M, month; ND, not determined; Chr, chromosome; Di, disomic; Tri, trisomic; Tet, tetrasomic.