Figure 1.

NMDA-induced hippocampal injury in neonatal rat brain. Twenty-micron coronal frozen brain sections were prepared from a P8 animal that had received a right intrahippocampal injection of 10 nmol of NMDA 24 hours earlier; the section was stained with cresyl violet to evaluate tissue integrity. Left panel: Intact contralateral hippocampus; right panel: loss of Nissl staining, which is maximal in the Cornu Ammon (CA)3 subfield of the right hippocampus (arrow). CC, corpus callosum; DG, dentate gyrus. Scale bar, 0.5 mm.