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. 1998 Nov;153(5):1501–1510. doi: 10.1016/S0002-9440(10)65738-0

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Copyright © 1998, American Society for Investigative Pathology

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Figure 2. — Enzyme cuts show higher amount of mutants in heart than in blood DNA. 1: Middle, A3260G, tRNA^LeuUUR; left, XmnI digestion in blood and in heart DNA; right, ultrastructural characteristics of the heart mitochondria with inclusion polygonal bodies. 2: Middle, T4314A, tRNA^Ile; left, MseI digestion in blood and in heart DNA; right, ultrastructural characteristics of the heart mitochondria with ring organelles. 3: Middle, A4315G, tRNA^Ile; left, MseI digestion in blood and inheart DNA; right, ultrastructural characteristics of the heart mitochondria with crystallized compacted cristae and osmiophilic bodies. 4: Middle, A5600T, tRNA^Ala; left, HinfI digestion in blood and in heart DNA; right, ultrastructural characteristics of the heart mitochondria with large organelles, devoid of cristae and often full of glycogen. 5: Middle, T7581C, tRNA^Asp; left, MnlI digestion in blood and in heart DNA; right, ultrastructural characteristics of the heart mitochondria with giant organelles, peripheral cristolysis, and central compacted cristae. 6: Middle, C14684T, tRNA^Glu; left, NlaIII digestion in blood and in heart DNA; right, ultrastructural characteristics of the heart mitochondria with concentrically arranged and undulated cristae. Uranyl acetate, lead citrate; magnification, ×6000.