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. 1998 Nov;153(5):1501–1510. doi: 10.1016/S0002-9440(10)65738-0

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Copyright © 1998, American Society for Investigative Pathology

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Figure 3. — Left column shows the heteroplasmy and the higher amount of mutant in heart than in blood DNA. 1: Middle, T15889C, tRNA^Thr; left, AvaII + digestion in blood and in heart DNA; right, ultrastructural characteristics of the heart mitochondria with concentric cristae and giant mitochondria. 2: Middle, A15902G, tRNA^Thr; left, MaeI digestion in blood and in heart DNA; right, ultrastructural characteristics of the heart mitochondria with giant organelles and undulated cristae. 3: Middle, A15935G, tRNA^Thr; left, MboII digestion in blood and in heart DNA; right, ultrastructural characteristics of the heart mitochondria with undulated, compacted cristae. 4: Middle, A1692T, 16 S rRNA; left MnlI digestion in blood and in heart DNA; right, ultrastructural characteristics of the heart mitochondria with giant organelles and crystallized compacted cristae. 5: Middle, C1703T, 16 S rRNA; left, PflMI digestion in blood and in heart DNA; right, ultrastructural characteristics of the heart mitochondria with giant organelles, peripheral cristolysis, and central compacted cristae. 6: Middle, T3197C, 16 S rRNA; left, MaeII digestion in blood and in heart DNA; right, ultrastructural characteristics of the heart mitochondria with giant organelles and undulate, swollen cristae. Uranyl acetate, lead citrate; magnification, ×6000.